Acute Care Treatment

Acute care treatment for Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) requires immediate medical attention and hospitalization, often in an intensive care unit or specialized burn unit. The first and most critical step in treatment is identifying and stopping the suspected triggering medication or underlying cause. Because SJS and TEN affect both the skin and mucous membranes, treatment focuses heavily on supportive care while the body begins to heal.

Patients typically require wound care similar to burn treatment, including sterile dressings, pain management, fluid and electrolyte replacement, nutritional support, and careful monitoring for infection. Eye involvement is common and may require urgent assessment and treatment by an ophthalmologist to help reduce the risk of long-term complications. Depending on the severity of the reaction and the patient's condition, additional treatments such as corticosteroids, intravenous immunoglobulin (IVIG), cyclosporine, or other immunomodulating therapies may be considered.

SJS and TEN can progress rapidly, making early recognition, prompt withdrawal of the offending medication, and specialized supportive care essential to improving outcomes and reducing the risk of complications or long-term effects.